VIP
$44.99
VIP (Vasoactive Intestinal Peptide) is a 28–amino acid neuropeptide that interacts with VPAC1 and VPAC2 receptors and is studied for its role in immune signaling, vascular regulation, circadian rhythm pathways, and neurological processes. VIP has been investigated in research settings across a range of physiological and inflammatory mechanisms.
Usage Disclaimer: Research Use Only. This product is intended strictly for laboratory research and in-vitro studies. It is not for human or animal consumption, medical use, or diagnostic purposes. Any unauthorized use of this product is strictly prohibited.
FDA Compliance: FDA Notice. The statements made regarding these products have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Research Studies
IV Aviptadil in Critical COVID-19 Respiratory Failure - Phase 2b/3 RCT (2022)
Humans | 196 patients | IV infusion | 60 days | 2-fold increased survival odds
Multicenter randomized controlled trial across 10 U.S. hospitals. Aviptadil showed 2-fold increased odds of 60-day survival (OR 2.0, p=0.035). Mechanically ventilated patients showed 10-fold increased survival odds. Significant reduction in IL-6 inflammatory marker.
VIP Corrects Chronic Inflammatory Response Syndrome (CIRS) (2013)
Humans | CIRS patients | Nasal spray 50mcg | Multiple months | Correction of inflammatory markers
Study demonstrating VIP nasal spray corrects CIRS acquired from water-damaged buildings. Showed correction of proteomics, transcriptomics, and gray matter nuclear atrophy refractory to other therapies.
IUPHAR Review: VIP and PACAP Receptor Pharmacology (2012)
Review | Comprehensive analysis of VPAC1/VPAC2/PAC1 receptors
Definitive pharmacological review of VIP receptors. Details mechanism of action through Gαs/cAMP/PKA pathway, physiological functions in CNS and periphery, and therapeutic potential for neurodegenerative, inflammatory, and autoimmune diseases.
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