PE 22-28
$52.99
10mg
PE-22-28 (Mini-Spadin) is a synthetic heptapeptide derived from a fragment of the parent peptide spadin. It has been studied in research settings for its interaction with TREK-1 potassium channel pathways and its role in neurophysiological signaling mechanisms related to mood and neuronal regulation.
Usage Disclaimer: Research Use Only. This product is intended strictly for laboratory research and in-vitro studies. It is not for human or animal consumption, medical use, or diagnostic purposes. Any unauthorized use of this product is strictly prohibited.
FDA Compliance: FDA Notice. The statements made regarding these products have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Research Studies
Spadin Selectively Antagonizes Arachidonic Acid Activation of TREK-1
Frontiers in Pharmacology 2020 | Mechanism of action study
Revealed Spadin and analogs specifically antagonize arachidonic acid-mediated TREK-1 activation via allosteric mechanism. This selective inhibition may explain favorable side effect profile compared to non-specific K+ channel blockers.
Role of TREK-1 in Health and Disease - CNS Focus
Frontiers in Physiology 2019 | Comprehensive review | Multiple disease states
Review establishing TREK-1's role in depression, neuroprotection, pain, and anesthesia. TREK-1 is highly expressed in prefrontal cortex, hippocampus, and amygdala - regions critical for mood and memory. Supports TREK-1 blockers as novel therapeutic approach.
Fighting Against Depression with TREK-1 Blockers
Pharmacology & Therapeutics 2019 | Review of Spadin research
Comprehensive review of TREK-1 as depression target and Spadin development. Highlighted rapid onset of action (4 days vs weeks for SSRIs), neurogenesis induction, and favorable safety profile in preclinical studies.
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