Dihexa
$34.99
Dihexa is a synthetic oligopeptide derived from angiotensin IV that has been studied for its interaction with pathways involved in neuronal signaling and synaptic processes. It is designed to cross the blood-brain barrier and has been investigated in research settings for its role in receptor-mediated activity and cellular communication within the central nervous system.
Dihexa is primarily used in scientific and investigational contexts to explore mechanisms related to synaptogenesis, neurotrophic signaling, and neural pathway modulation.
Usage Disclaimer: Research Use Only. This product is intended strictly for laboratory research and in-vitro studies. It is not for human or animal consumption, medical use, or diagnostic purposes. Any unauthorized use of this product is strictly prohibited.
FDA Compliance: FDA Notice. The statements made regarding these products have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Research Studies
APP/PS1 Alzheimer's Mouse Model Study (2021)
Mice | 1.44-2.88 mg/kg oral | 3 months | Cognitive rescue via PI3K/AKT pathway
Dihexa restored spatial learning and memory in Morris water maze tests, increased neuronal cells and synaptophysin expression, reduced neuroinflammation, and decreased glial activation in Alzheimer's model mice.
Synaptogenic Potency Comparison (2014)
In vitro | 10^-12 M | Synapse formation assays | 7 orders magnitude > BDNF
Demonstrated Dihexa's remarkable potency, showing it to be 10 million times more effective than BDNF at promoting synapse formation through HGF/c-Met receptor activation.
Injectable Route Efficacy Study (2013)
Rats | 0.05-0.5 mg/kg IP injection | Daily | Complete cognitive restoration
Intraperitoneal injection at 0.5 mg/kg/day completely reversed scopolamine-induced cognitive deficits (p<0.001), with performance indistinguishable from healthy controls. Lower doses (0.15 mg/kg) showed partial benefits. Also tested IV and ICV routes successfully.
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