Adipotide
$56.99
5mg
Adipotide (Prohibitin-TP01) is a synthetic peptidomimetic studied for its targeted interaction with proteins expressed on adipose tissue vasculature, including prohibitin and annexin A2. It incorporates a pro-apoptotic peptide motif and has been evaluated in preclinical and early clinical research for its role in adipose tissue–related cellular signaling mechanisms.
Usage Disclaimer: Research Use Only. This product is intended strictly for laboratory research and in-vitro studies. It is not for human or animal consumption, medical use, or diagnostic purposes. Any unauthorized use of this product is strictly prohibited.
FDA Compliance: FDA Notice. The statements made regarding these products have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Research Studies
Human adipose targeting – imaging validation (2018)
Human adipose tissue (ex vivo) & mouse in vivo | CKGGRAKDC MRI probe | Single/short courses | Specific WAT targeting demonstrated
Molecular MRI using CKGGRAKDC confirmed prohibitin‑based adipose targeting, supporting the translational targeting concept.
Obese rhesus macaques – fixed‑dose efficacy & safety (2011)
Rhesus macaques | 0.43 mg/kg SC daily | 28 days + 28‑day recovery | 7.4–14.7% weight loss; insulin resistance improved; mild, dose‑dependent, reversible proximal tubule changes
White‑adipose vasculature targeting led to rapid fat mass reduction and improved insulin dynamics. Kidney signals (creatinine rise, tubular changes) were dose‑related and largely reversible after discontinuation.
Rhesus macaques – dose‑finding (2011)
Rhesus macaques | 0.10 → 0.25 → 0.43 → 0.75 mg/kg SC (escalated) | 63 days total | Dose‑dependent efficacy; renal safety signal >0.25 mg/kg
Identified 0.43 mg/kg SC daily as the optimal primate dose balancing efficacy and renal safety for subsequent fixed‑dose testing.
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